{"id":3777,"date":"2025-07-28T11:15:19","date_gmt":"2025-07-28T03:15:19","guid":{"rendered":"https:\/\/www.pgeneral.com\/?p=3777"},"modified":"2025-07-28T11:15:19","modified_gmt":"2025-07-28T03:15:19","slug":"case-sharing-of-persee-a500-zeeman-atomic-absorption-spectrophotometer-in-the-detection-of-lead-in-blood-and-additives","status":"publish","type":"post","link":"https:\/\/www.pgeneral.com\/tr\/applications\/case-sharing-of-persee-a500-zeeman-atomic-absorption-spectrophotometer-in-the-detection-of-lead-in-blood-and-additives","title":{"rendered":"Persee A500 Zeeman Atomik Emme Spektrofotometrinin Kan ve Katk\u0131 Maddelerindeki Kur\u015fun Tespitinde Vaka Payla\u015f\u0131m\u0131"},"content":{"rendered":"<p>Kandaki kur\u015fun i\u00e7eri\u011fi (kan kur\u015funu) insan v\u00fccudundaki kur\u015fun maruz kalma seviyesini \u00f6l\u00e7mek i\u00e7in \u00f6nemli bir g\u00f6stergedir. Toksik bir a\u011f\u0131r metal olarak, kur\u015fun, \u00f6zellikle \u00e7ocuklar ve hamile kad\u0131nlar \u00fczerinde \u00f6nemli bir etkisi olan d\u00fc\u015f\u00fck konsantrasyonlarda bile insan sa\u011fl\u0131\u011f\u0131na zarar verebilir.<\/p>\n<p>Kan kur\u015fun seviyeleri, \u00e7e\u015fitli kurumlar aras\u0131nda biraz farkl\u0131 standartlarla desiliter ba\u015f\u0131na mikrogram (\u03bcg \/ dL) olarak \u00f6l\u00e7\u00fcl\u00fcr:<\/p>\n<p>\u00c7ocuklar i\u00e7in (0-18 ya\u015f):<\/p>\n<ul>\n<li>ABD CDC, \u22655\u03bcg \/ dL seviyelerinin dikkat gerektirmesini \u00f6nerir (g\u00fcvenli e\u015fik yoktur, ancak daha d\u00fc\u015f\u00fck daha iyidir);<\/li>\n<li>\u00c7in standartlar\u0131: \u226510\u03bcg \/ dL kur\u015fun zehirlenmesi olarak kabul edilir (\u226545\u03bcg \/ dL \u015fiddetli olan hafif, orta ve \u015fiddetli olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r).<\/li>\n<\/ul>\n<p>Yeti\u015fkinler i\u00e7in:<\/p>\n<ul>\n<li>Normal aral\u0131k: &lt; 10 \u03bcg \/ dL;<\/li>\n<li>Mesleki maruz kalma s\u0131n\u0131r\u0131: \u00c7in'de, mesleki maruz kalan ki\u015filerin kan kur\u015fun seviyesi \u226540\u03bcg \/ dL oldu\u011funda m\u00fcdahale gereklidir.<\/li>\n<\/ul>\n<p>2006 y\u0131l\u0131nda \u00c7in Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 &#8220; \u00c7ocukluk Hiperledemisi ve Kur\u015fun Zehirlenmesinin S\u0131n\u0131fland\u0131r\u0131lmas\u0131 ve Y\u00f6netimi \u0130\u00e7in K\u0131lavuzlar (Deneme),&#8221; zehirlenme seviyelerini a\u015fa\u011f\u0131daki gibi a\u00e7\u0131k\u00e7a tan\u0131mlayan:<\/p>\n<p>&#8220; \u00c7ocukluk hiperleademisi ve kur\u015fun zehirlenmesi \u00e7ocuklara dayanarak te\u015fhis edilir&#8217; Venoz kan kur\u015fun seviyeleri.<\/p>\n<p>Hiperledemi: 100-199\u03bcg \/ L'lik iki ard\u0131c\u0131l ven\u00f6z kan kur\u015fun seviyesi;<\/p>\n<p>Kur\u015fun zehirlenmesi: 200 \u03bcg \/ L'den e\u015fit veya daha y\u00fcksek iki ard\u0131c\u0131l ven\u00f6z kan kur\u015fun seviyesi; ve kan kur\u015fun seviyelerine g\u00f6re hafif, orta ve \u015fiddetli kur\u015fun zehirlenmesine s\u0131n\u0131fland\u0131r\u0131l\u0131r.<\/p>\n<p>Hafif kur\u015fun zehirlenmesi: Kan kur\u015fun seviyesi 200-249\u03bcg \/ L;<\/p>\n<p>Orta derecede kur\u015fun zehirlenmesi: 250-449\u03bcg \/ L kan kur\u015fun seviyesi;<\/p>\n<p>A\u011f\u0131r kur\u015fun zehirlenmesi: Kan kur\u015fun seviyesi 450 \u03bcg \/ L'den e\u015fit veya daha y\u00fcksek;<\/p>\n<p>\u00c7ocukluk kur\u015fun zehirlenmesi, kar\u0131n s\u0131k\u0131c\u0131 a\u011fr\u0131s\u0131, kab\u0131zl\u0131k, anemi, hiperaktivite ve impulsivite gibi belirli spesifik olmayan klinik semptomlarla e\u015flik edebilir; Kan kur\u015fun seviyeleri 700 \u03bcg \/ L'den e\u015fit veya daha y\u00fcksek oldu\u011funda, koma ve konv\u00fclsiyonlar gibi kur\u015fun ensefalopati belirtileri e\u015flik edebilir. &#8221;<\/p>\n<p>&nbsp;<\/p>\n<p><strong><b>Kan Kur\u015fun Tespitinde Zorluklar ve Standartlar<\/b><\/strong><\/p>\n<p>Bu bebek kan kur\u015funu olay\u0131nda, farkl\u0131 kurumlar veya hastaneler taraf\u0131ndan sa\u011flanan kan kur\u015funu verilerinde, yarg\u0131 sonu\u00e7lar\u0131n\u0131 etkileyen \u00f6nemli farkl\u0131l\u0131klar vard\u0131.<\/p>\n<p>S\u0131n\u0131rl\u0131 kan \u00f6rne\u011fi hacmi, aletlerin operasyonel kolayl\u0131\u011f\u0131 ve maliyet yat\u0131r\u0131m\u0131 gibi sorunlar nedeniyle, grafit f\u0131r\u0131n atomik emim spektrofotometrleri \u015fu anda kan kur\u015funu tespiti i\u00e7in en uygun aletlerdir. \u00c7\u00fcnk\u00fc kan, test s\u0131ras\u0131nda kolayca arka plan sinyalleri olu\u015fturan b\u00fcy\u00fck miktarda protein, organik madde ve di\u011fer bile\u015fenler i\u00e7erir. Grafit f\u0131r\u0131n atomik emim y\u00f6ntemi kullanarak kan kur\u015funu testi i\u00e7in standartlar iki arka plan d\u00fczeltme tekni\u011fi (deuterium lambas\u0131 \/ Zeeman) \u00f6nerir. Arka plan d\u00fczeltme teknolojisi \u00f6rnek matrislerinden m\u00fcdahaleyi etkili bir \u015fekilde kald\u0131rabilir, tespit duyarl\u0131l\u0131\u011f\u0131n\u0131 art\u0131rabilir ve test verilerinin do\u011frulu\u011funu sa\u011flayabilir. Bununla birlikte, deuterium lambas\u0131 arka plan d\u00fczeltmesinin nispeten standart sapma aral\u0131\u011f\u0131, Zeeman arka plan d\u00fczeltme teknolojisinden daha y\u00fcksek (% 1,6 ~ 2,8%, n = 6) olan% 1,5 ~ 5,3'd\u00fcr. Bu nedenle, Zeeman arka plan d\u00fczeltme atomik emim y\u00f6ntemi daha do\u011fru kan kur\u015funu verileri elde edebilir.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><b>Teknolojik Destek: P taraf\u0131ndan do\u011fru tespit<\/b><\/strong><strong><b>ersee'nin<\/b><\/strong><strong><b>\u00a0A500 Zeeman Atom Emme Spektrofotometri<\/b><\/strong><\/p>\n<p>Persee, yakla\u015f\u0131k 30 y\u0131ld\u0131r atomik emim spektrofotometrleri alan\u0131nda derinden me\u015fgul olmu\u015ftur ve b\u00f6ylece, referans olarak kullan\u0131labilen kandaki kur\u015fun ve katk\u0131 maddelerinin tespit y\u00f6ntemleri hakk\u0131nda yeterli veri do\u011frulamas\u0131 ger\u00e7ekle\u015ftirdi.<\/p>\n<ol>\n<li><strong><b> Standart Madde Y\u00f6ntemi &#8211; Kandaki Kur\u015fun Belirlenmesi<\/b><\/strong><\/li>\n<\/ol>\n<p>Referans standart\u0131: &#8220; GBZ \/ T 316.1-2018 Kandaki Kur\u015funun Belirlenmesi B\u00f6l\u00fcm 1: Grafit F\u0131r\u0131n\u0131 Atom Emme Spektrometrisi&#8221;<\/p>\n<p>Tespit ekipman\u0131: A500G Zeeman Grafit F\u0131r\u0131n\u0131 Atom Emme Spektrofotometri<\/p>\n<p>Standart maddeler: GSB 04-1742-2004 Kur\u015fun Tek Elemanl\u0131 \u00c7\u00f6z\u00fcm Standart Madde<\/p>\n<p>Standart \u00f6rnekler: Dondurulmu\u015f s\u0131\u011f\u0131r kan\u0131 kur\u015funu ve kadmium bile\u015feni analizi standart maddeleri; GBW09139 (107 \u00b1 15\u03bcg \/ L), GBW09140 (318 \u00b1 12\u03bcg \/ L)<\/p>\n<p>Deneysel sonu\u00e7: Yukar\u0131daki veriler, iki grafit f\u0131r\u0131n\u0131n atomik emim y\u00f6ntemlerinin kalibrasyon e\u011frilerinin korelasyon katsay\u0131lar\u0131n\u0131n her ikisinin &gt; oldu\u011funu g\u00f6stermektedir. 0.999, iyi do\u011frusal. Her ikisi de tespit standart y\u00f6nteminde belirtilen 20 \u03bcg\/L'den daha d\u00fc\u015f\u00fckt\u00fcr. Dondurulmu\u015f s\u0131\u011f\u0131r kan\u0131 standart maddelerinin test sonu\u00e7lar\u0131 belirlenmi\u015f aral\u0131klar\u0131nda bulunmaktad\u0131r.<\/p>\n<ol start=\"2\">\n<li><strong><b> Standart Ekleme Y\u00f6ntemi &#8211; Katk\u0131 maddelerindeki kur\u015funun belirlenmesi<\/b><\/strong><\/li>\n<\/ol>\n<p>Referans standartlar\u0131: &#8220; GB \/ T 13080-2018 Yem Atom Emme Spektrometrisinde Kur\u015funun Belirlenmesi&#8221;  (tahkim y\u00f6ntemi &#8211; grafit f\u0131r\u0131n y\u00f6ntemi, \u00f6nerilen ko\u015ful: Zeeman arka plan d\u00fczeltme teknolojisi), &#8220; GB 34459-2017 Yem Katk\u0131 Bak\u0131r S\u00fclfat &#8221; , &#8220; GB 34465-2017 Yem Katk\u0131 Demir S\u00fclfat &#8221;.<\/p>\n<p>Tespit ekipman\u0131: A500G Zeeman Alev Atom Emme Spektrofotometri<\/p>\n<p>Standart madde: GSB 04-1742-2004 Kur\u015fun Tek Elemanl\u0131 \u00c7\u00f6z\u00fcm Standart Madde<\/p>\n<p>\u00d6rnekler: Yem katk\u0131 maddeleri, bak\u0131r s\u00fclfat, demir s\u00fclfat (y\u00fcksek tuzlu arka plan \u00f6rnekleri)<\/p>\n<p>Deneysel sonu\u00e7: GB\/T 13080-2018, alev atomik emim spektrometrisinin miktarl\u0131k s\u0131n\u0131r\u0131n\u0131n 2mg\/kg oldu\u011funu ve aletin ger\u00e7ek \u00f6l\u00e7\u00fclm\u00fc\u015f alg\u0131lama s\u0131n\u0131r\u0131n\u0131n 0,50mg\/kg oldu\u011funu belirtiyor, bu da alg\u0131lama standart\u0131n\u0131n gereksinimlerini kar\u015f\u0131l\u0131yor; iki katk\u0131 maddesi \u00e7ift noktal\u0131 spiking i\u00e7in se\u00e7ildi ve geri kazanma oran\u0131 standart kalite kontrol gereksinimlerini kar\u015f\u0131layan% 95,9 ~ 104,6'yd\u0131.<\/p>\n<p>Sonu\u00e7ta, A500 atomik emim spektrofotometri, kandaki kur\u015fun ve katk\u0131 maddelerinin belirlenmesinde istikrarl\u0131 ve g\u00fcvenilir tespit verileri sa\u011flayabilir.<\/p>\n<p><strong><b>Verimli Tespit ile Gelece\u011fi Korumak<\/b><\/strong><\/p>\n<p>Kur\u015fun kirlili\u011fi g\u00f6z ard\u0131 edilemez ve bilimsel tespit sa\u011fl\u0131k korumas\u0131n\u0131n ilk savunma hatt\u0131d\u0131r. \u0130ster halk sa\u011fl\u0131\u011f\u0131 acil durumlar\u0131 olsun, ister g\u00fcnl\u00fck g\u0131da g\u00fcvenli\u011fi izleme olsun, geli\u015fmi\u015f tespit teknolojisi her zaman halk sa\u011fl\u0131\u011f\u0131n\u0131n korunmas\u0131 i\u00e7in \u00f6nemli bir temel ta\u015f\u0131 olmu\u015ftur. Puxi A500 serisi atomik emim spektrofotometri, teknolojik g\u00fc\u00e7l\u00fc kan kur\u015funu tespiti i\u00e7in verimli ve g\u00fcvenilir bir \u00e7\u00f6z\u00fcm sa\u011flar. Gelecekte sa\u011fl\u0131k ve g\u00fcvenli\u011fi korumak i\u00e7in daha yenilik\u00e7i teknolojiler i\u00e7in sab\u0131rs\u0131zlan\u0131yoruz.<\/p>\n<p><strong><b>A500 Atomik Emme Spektrofotometri'ne Giri\u015f<\/b><\/strong><\/p>\n<p><strong><b><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-3778\" src=\"http:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2-300x169.png\" alt=\"\" width=\"300\" height=\"169\" srcset=\"https:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2-300x169.png 300w, https:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2-768x434.png 768w, https:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2-18x10.png 18w, https:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2-600x339.png 600w, https:\/\/www.pgeneral.com\/wp-content\/uploads\/2025\/07\/\u56fe\u72471-2.png 1020w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\u00a0<\/b><\/strong><\/p>\n<p>\u00dcst\u00fcn Performans<\/p>\n<p>Toplam yans\u0131ma asferik akromatik optik sistemi, kendi kendine geli\u015ftirilen ultraviyole y\u00fcksek yans\u0131t\u0131c\u0131 kaplama teknolojisini benimseyerek, m\u00fckemmel bir nokta b\u00fct\u00fcnl\u00fc\u011f\u00fc ve \u0131\u015f\u0131k ak\u0131\u015f\u0131n\u0131 elde eder ve aletin sinyal-g\u00fcr\u00fclt\u00fc oran\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde iyile\u015ftirir.<\/p>\n<p>M\u00fckemmel istikrarl\u0131 entegre optik platform:<\/p>\n<p>M\u00fckemmel termal istikrar ve \u015fok direnci sa\u011flamak i\u00e7in entegre bir platform tasar\u0131m\u0131 ve makul bir cihaz d\u00fczeni benimsemek.<\/p>\n<p>S\u00fcper g\u00fc\u00e7l\u00fc arka plan d\u00fczeltme yetene\u011fi:<\/p>\n<p>Hem alev hem de grafit f\u0131r\u0131n, tam dalga boyu aral\u0131\u011f\u0131nda Zeeman arka plan d\u00fczeltmesini ger\u00e7ekle\u015ftirebilen, 1Abs'te 150'den fazla ve 2Abs'te 100'den fazla arka plan d\u00fczeltme performans\u0131n\u0131 elde edebilen kutupla\u015fm\u0131\u015f Zeeman modunu benimser.<\/p>\n<p>Ger\u00e7ek zamanl\u0131 \u00e7ift detekt\u00f6rler, uzun vadeli \u00e7al\u0131\u015fma istikrar\u0131 i\u00e7in faydal\u0131:<\/p>\n<p>Kutaplanm\u0131\u015f \u0131\u015f\u0131\u011f\u0131n iki yolu, do\u011fru alg\u0131lama sonu\u00e7lar\u0131 elde etmek i\u00e7in ger\u00e7ek zamanl\u0131 olarak arka plan d\u00fczeltmesi yapabilen ayn\u0131 anda \u00e7al\u0131\u015fan \u00e7ift dedekt\u00f6rlere kar\u015f\u0131l\u0131k gelir.<\/p>","protected":false},"excerpt":{"rendered":"<p>The lead content in blood (blood lead) is an important indicator to measure the level of lead exposure in the human body. As a toxic heavy metal, lead can cause harm to human health even at low concentrations, especially having a significant impact on children and pregnant women. Blood lead levels are measured in micrograms [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[36,77],"tags":[],"class_list":["post-3777","post","type-post","status-publish","format-standard","hentry","category-applications","category-bio-tech-and-life-sciences"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/posts\/3777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/comments?post=3777"}],"version-history":[{"count":0,"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/posts\/3777\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/media?parent=3777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/categories?post=3777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pgeneral.com\/tr\/wp-json\/wp\/v2\/tags?post=3777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}